Our laboratory studies dynamic properties of proteins and large protein complexes in cellular environments by using a variety of techniques in biochemistry, molecular biology and cellular biology, in combination with nano-technology and computational simulation.


Specific research topics include:
 ・Understanding molecular mechanism and biophysical background of mitotic chromosome condensation
 ・Single-molecule imaging of higher-order architectures of DNA, RNA and various nucleoprotein complexes
 ・Non-invasive imaging of membrane and cytoskeletal dynamics by fast-scanning atomic force microscopy
 ・Understanding physical and chemical mechanisms of subunit assembly and disassembly of nuclear pore complex
 ・Structural dynamics of flexible and repetitive proteins in intracellular environments and molecular crowding


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